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Photoplethysmography | |
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Representative PPG taken from an ear pulse oximeter. Variation in amplitude are from Respiratory Induced Variation. | |
MeSH | D017156 |
A photoplethysmogram (PPG) is an optically obtained plethysmogram that can be used to detect blood volume changes in the microvascular bed of tissue. A PPG is often obtained by using a pulse oximeter which illuminates the skin and measures changes in light absorption.[1] A conventional pulse oximeter monitors the perfusion of blood to the dermis and subcutaneous tissue of the skin.
With each cardiac cycle the heart pumps blood to the periphery. Even though this pressure pulse is somewhat damped by the time it reaches the skin, it is enough to distend the arteries and arterioles in the subcutaneous tissue. If the pulse oximeter is attached without compressing the skin, a pressure pulse can also be seen from the venous plexus, as a small secondary peak.
The change in volume caused by the pressure pulse is detected by illuminating the skin with the light from a light-emitting diode (LED) and then measuring the amount of light either transmitted or reflected to a photodiode.[2] Each cardiac cycle appears as a peak, as seen in the figure. Because blood flow to the skin can be modulated by multiple other physiological systems, the PPG can also be used to monitor breathing, hypovolemia, and other circulatory conditions.[3] Additionally, the shape of the PPG waveform differs from subject to subject, and varies with the location and manner in which the pulse oximeter is attached.
Sites for measuring PPG[edit]
While pulse oximeters are a commonly used medical device, the PPG derived from them is rarely displayed and is nominally only processed to determine heart rate. PPGs can be obtained from transmissive absorption (as at the finger tip) or reflection (as on the forehead).
In outpatient settings, pulse oximeters are commonly worn on the finger. However, in cases of shock, hypothermia, etc. blood flow to the periphery can be reduced, resulting in a PPG without a discernible cardiac pulse.[4] In this case, a PPG can be obtained from a pulse oximeter on the head, with the most common sites being the ear, nasal septum, and forehead. PPG can also be configured as multi-site photoplethysmography (MPPG), e.g. making simultaneous measurements from the right and left ear lobes, index fingers and great toes, and offering further opportunities for the assessment of patients with suspected peripheral arterial disease, autonomic dysfunction, endothelial dysfunction, and arterial stiffness. MPPG also offers significant potential for data mining, e.g. using deep learning, as well as a range of other innovative pulse wave analysis techniques. [5][6][7][8]
Motion artifacts have been shown to be a limiting factor preventing accurate readings during exercise and free living conditions.
Uses[edit]
Monitoring heart rate and cardiac cycle[edit]
Because the skin is so richly perfused, it is relatively easy to detect the pulsatile component of the cardiac cycle. The DC component of the signal is attributable to the bulk absorption of the skin tissue, while the AC component is directly attributable to variation in blood volume in the skin caused by the pressure pulse of the cardiac cycle.
The height of AC component of the photoplethysmogram is proportional to the pulse pressure, the difference between the systolic and diastolic pressure in the arteries. As seen in the figure showing premature ventricular contractions (PVCs), the PPG pulse for the cardiac cycle with the PVC results in lower amplitude blood pressure and a PPG. Ventricular tachycardia and ventricular fibrillation can also be detected.[9]
Monitoring respiration[edit]
Respiration affects the cardiac cycle by varying the intrapleural pressure, the pressure between the thoracic wall and the lungs. Since the heart resides in the thoracic cavity between the lungs, the partial pressure of inhaling and exhaling greatly influence the pressure on the vena cava and the filling of the right atrium.
During inspiration, intrapleural pressure decreases by up to 4 mm Hg, which distends the right atrium, allowing for faster filling from the vena cava, increasing ventricular preload, but decreasing stroke volume. Conversely during expiration, the heart is compressed, decreasing cardiac efficiency and increasing stroke volume. When the frequency and depth of respiration increases, the venous return increases, leading to increased cardiac output.[11]
Monitoring depth of anesthesia[edit]
Anesthesiologists must often judge subjectively whether a patient is sufficiently anesthetized for surgery. As seen in the figure, if a patient is not sufficiently anesthetized, the sympathetic nervous system response to an incision can generate an immediate response in the amplitude of the PPG.[10]
Monitoring hypo- and hypervolemia[edit]
Shamir, Eidelman, et al. studied the interaction between inspiration and removal of 10% of a patient’s blood volume for blood banking before surgery.[12] They found that blood loss could be detected both from the photoplethysmogram from a pulse oximeter and an arterial catheter. Patients showed a decrease in the cardiac pulse amplitude caused by reduced cardiac preload during exhalation when the heart is being compressed.
Monitoring blood pressure[edit]
The FDA reportedly provided clearance to a photoplethysmography-based cuffless blood pressure monitor in August 2019.[13]
Remote photoplethysmography[edit]
Conventional imaging[edit]
While photoplethysmography commonly requires some form of contact with the human skin (e.g., ear, finger), remote photoplethysmography allows to determine physiological processes such as blood flow without skin contact. This is achieved by using face video to analyze subtle momentary changes in the subject's skin color which are not detectable to the human eye.[14][15] Such camera-based measurement of blood oxygen levels provides a contactless alternative to conventional photoplethysmography. For instance, it can be used to monitor the heart rate of newborn babies,[16] or analyzed with deep neural networks to quantify stress levels.[17]
Digital holography[edit]
Remote photoplethysmography can also be performed by digital holography, which is sensitive to the phase of light waves, and hence can reveal sub-micron out-of-plane motion. In particular, wide-field imaging of pulsatile motion induced by blood flow can be measured on the thumb by digital holography. The results are comparable to blood pulse monitored by plethysmoraphy during an occlusion-reperfusion experiment.[18] A major advantage of this system is that no physical contact with the studied tissue surface area is required.
A refinement of this technique, holographic laser Doppler imaging, enables non-invasive retinal and choroidal blood flow pulse wave monitoring.[19]In laser Doppler holography of the eye fundus, the choroid constitutes the predominant contribution to the high frequency laser Doppler signal. It is however possible to circumvent its influence by subtracting the spatially averaged baseline signal, and achieve high temporal resolution and full-field imaging capability of pulsatile blood flow.
See also[edit]
References[edit]
- ^K. Shelley and S. Shelley, Pulse Oximeter Waveform: Photoelectric Plethysmography, in Clinical Monitoring, Carol Lake, R. Hines, and C. Blitt, Eds.: W.B. Saunders Company, 2001, pp. 420-428.
- ^E. Aguilar Pelaez et al., 'LED power reduction trade-offs for ambulatory pulse oximetry,' 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Lyon, 2007, pp. 2296-2299.doi: 10.1109/IEMBS.2007.4352784, URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4352784&isnumber=4352185
- ^Reisner A, Shaltis PA, McCombie D, Asada HH (May 2008). 'Utility of the photoplethysmogram in circulatory monitoring'. Anesthesiology. 108 (5): 950–8. doi:10.1097/ALN.0b013e31816c89e1. PMID18431132.
- ^Budidha, K; Kyriacou, PA (August 2015). 'Investigation of photoplethysmography and arterial blood oxygen saturation from the ear-canal and the finger under conditions of artificially induced hypothermia'(PDF). Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2015: 7954–7. doi:10.1109/EMBC.2015.7320237. ISBN978-1-4244-9271-8. PMID26738137. S2CID4574235.
- ^Allen, John; Overbeck, Klaus; Nath, Alexander F.; Murray, Alan; Stansby, Gerard (Apr 2008). 'A prospective comparison of bilateral photoplethysmography versus the ankle-brachial pressure index for detecting and quantifying lower limb peripheral arterial disease'. J Vasc Surg. 47 (4): 794–802. doi:10.1016/j.jvs.2007.11.057. PMID18381141.
- ^McKay, N. D.; Griffiths, B.; Di Maria, C.; Hedley, S.; Murray, A.; Allen, J. (Oct 2014). 'Novel photoplethysmography cardiovascular assessments in patients with Raynaud's phenomenon and systemic sclerosis: a pilot study'. Rheumatology (Oxford). 53 (10): 1855–63. doi:10.1093/rheumatology/keu196. PMID24850874.
- ^Mizeva, Irina; Di Maria, Costanzo; Frick, Peter; Podtaev, Sergey; Allen, John (Mar 2015). 'Quantifying the correlation between photoplethysmography and laser Doppler flowmetry microvascular low-frequency oscillations'. J Biomed Optics. 20 (3): 037007. Bibcode:2015JBO....20c7007M. doi:10.1117/1.JBO.20.3.037007. PMID25764202. S2CID206437523.
- ^Al-Jebrni, Abdulrhman H.; Chwyl, Brendan; Wang, Xiao Yu; Wong, Alexander; Saab, Bechara J. (2020-05-01). 'AI-enabled remote and objective quantification of stress at scale'. Biomedical Signal Processing and Control. 59: 101929. doi:10.1016/j.bspc.2020.101929. ISSN1746-8094.
- ^Alian, AA; Shelley, KH (December 2014). 'Photoplethysmography'. Best Practice & Research. Clinical Anaesthesiology. 28 (4): 395–406. doi:10.1016/j.bpa.2014.08.006. PMID25480769.
- ^ abShelley, KH (December 2007). 'Photoplethysmography: beyond the calculation of arterial oxygen saturation and heart rate'. Anesthesia and Analgesia. 105 (6 Suppl): S31–6, tables of contents. doi:10.1213/01.ane.0000269512.82836.c9. PMID18048895. S2CID21556782.
- ^Shelley, KH; Jablonka, DH; Awad, AA; Stout, RG; Rezkanna, H; Silverman, DG (August 2006). 'What is the best site for measuring the effect of ventilation on the pulse oximeter waveform?'. Anesthesia and Analgesia. 103 (2): 372–7, table of contents. doi:10.1213/01.ane.0000222477.67637.17. PMID16861419. S2CID6926327.
- ^M. Shamir, L. A. Eidelman, Y. Floman, L. Kaplan, and R. Pi-zov, Pulse Oximetry Plethysmographic Waveform During Changes in Blood Volume, Br. J. Anaesth., vol. 82, pp. 178-181, 1999.
- ^Wendling, Patrice (28 August 2019). 'FDA Okays Biobeat's Cuffless Blood Pressure Monitor'. Medscape. Retrieved 5 September 2019.
- ^Verkruysse, W.; Svaasand, L.O.; Nelson, J.S. (2008). 'Remote plethysmographic imaging using ambient light'. Optics Express. 16 (26): 21434–21445. Bibcode:2008OExpr..1621434V. doi:10.1364/OE.16.021434. PMC2717852. PMID19104573.
- ^Rouast, P.V.; Adam, M.T.P.; Chiong, R.; Cornforth, D.; Lux, E. (2018). 'Remote heart rate measurement using low-cost RGB face video: A technical literature review'. Frontiers of Computer Science. 12 (5): 858–872. doi:10.1007/s11704-016-6243-6. S2CID1483621.
- ^https://www.youtube.com/watch?v=7Nq73-jYbpY
- ^Al-Jebrni, Abdulrhman H.; Chwyl, Brendan; Wang, Xiao Yu; Wong, Alexander; Saab, Bechara J. (2020-05-01). 'AI-enabled remote and objective quantification of stress at scale'. Biomedical Signal Processing and Control. 59: 101929. doi:10.1016/j.bspc.2020.101929. ISSN1746-8094.
- ^Bencteux, Jeffrey (2015). 'Holographic laser Doppler imaging of pulsatile blood flow'. Journal of Biomedical Optics. 20 (6): 066006. arXiv:1501.05776. Bibcode:2015JBO....20f6006B. doi:10.1117/1.JBO.20.6.066006. PMID26085180. S2CID20234484.
- ^Puyo, L., M. Paques, M. Fink, J-A. Sahel, and M. Atlan. 'In vivo laser Doppler holography of the human retina.' Biomedical optics express 9, no. 9 (2018): 4113-4129.
Are these gears are a direct fit in my Subaru 5-speed? The answer depends on the model and year. These gears are designed around the early (1999-2002) WRX transmission so fitment to other models may require backdating some parts. Additionally, the gear width of 1st,2nd, and 3rd is narrower than the later gears. If changing only 1st and 2nd gears on MY2003+ either MY2002 WRX 3rd and 4th gears must be used or some custom work is necessary for correct fitment. We suggest only experienced PPG installers attempt this work. Please contact us for additional information.
Ppg Transmission Honda
How does a synchronizer function? A synchronizer gear set uses a baulk ring (also known as a blocking ring) to prevent the selection of the gear until a friction surface on the baulk ring has synchronized the speed of the gear to the speed of the output shaft. The synchronizer's operation relies primarily on the viscous drag of the fluid but as the fluid between the baulk ring and the mating surface on the gear is squeezed out friction between the baulk ring and the cone becomes the only synchronizing mechanism. An attempt to shift too quickly or with too great of a speed differential (mis-shift) will cause wear and damage to the baulk ring and potentially the selector engagement teeth making subsequent shifting into that gear more difficult. A synchronizer is very sensitive to the viscosity and the friction characteristics of the fluid and the selection of the wrong fluid can cause shifting issues.
How does a dog type gearbox function? A dogbox has no synchronizing function. A set of dogs (basically raised metal blocks machined on the face of the gear) engage instantaneously with a set of matching cutouts in the selector sleeve. The cutouts on the sleeve are much wider than the dogs so the dogs will drop in to the cutouts easily. A slight back cut on the dog and sleeve prevents the dogs from disengaging when under load. The speed of the shift is limited only by how quickly the driver can move the shifter and in some cases the shift can be made without disengaging the clutch. Shifting must be quick and deliberate or the dogs will clash which damages their corners. With enough damage the dogs will not stay engaged under load and will need to be replaced or re-cut. The life expectancy of the dogs is entirely dependent on how well it is shifted. However, a dogbox is preferred for competition use because it allows faster shifts and can allow shifts to occur even under the most adverse conditions that would destroy a synchronizer.
What is a sequential gearbox? A sequential gearbox is a dogbox with a special shifter mechanism. The shifter moves only forward and backward (it is not an 'H' pattern with separate gates like a traditional gearbox). The gear selection must be done in sequence (hence 'sequential'). Pulling backward on the shifter will shift up while pushing forward will shift down. To put the transmission in nuetral shift down to 1st and then down again. Reverse is selected from nuetral after releasing a lockout lever. The advantage of a sequential gearbox is to provide the quickest and most mistake-free shifting. It is impossible to accidentally downshift into an incorrect gear and drastically overrev the engine.
What is the difference between a straight cut and helical cut gear? This is a representation of the tooth profile. A straight cut gear is machined perpendicular to the faces of the gear...or basically straight across. A helical gear is machined along a helix and will have some angle and curvature to the tooth. Straight cut gear teeth engage one at a time all at once. When each tooth engages, due to the backlash in the gears, a clicking noise is generated and as this happens one after another repeatedly at high speeds the result is the characteristic gear whine noise. Helically cut gears engage gradually with some sliding motion.
What are the advantages and disadvantages to the different tooth profiles? A straight cut gear is typically used for a racing application because when load is applied to the gear teeth there is no, or very little, axial thrust component to the resulting forces generated. A straight cut gear is therefore more efficient as the power wasted in the bearings is reduced. Additionally, a straight cut tooth profile is more forgiving to shaft deflections that allow the gear teeth to separate from each other under load or heavy shock. A helical gear is quiet with little or no whine (depending on the helix angle as well as the accuracy of the tooth profile). This makes it more preferrable for a road car. Additionally, a helical gear will typically have a greater load capacity (assuming identical gear tooth pitch and other dimensions) although as mentioned will have much less tolerance to gear mesh issues due to gear tooth separation conditions.
What is a close ratio gear set? Close ratio means the ratio difference between adjacent gears is smaller so the rpm change with each shift is reduced. This allows the engine to operate within a narrower rpm range which may be beneficial for acceleration particularly if the engine has a 'peaky' power curve. In general a close ratio set will be more fun to drive on tight twisty roads. However, the taller 1st gear demands that the clutch be slipped a little more in order to get the car moving and the shorter 5th gear will raise the highway rpms and potentially reduce the fuel economy.
How strong are the PPG gears? Compared to OEM and some lesser quality aftermarket gears PPG uses a special tooth profile, larger tooth dimensions, higher quality materials, and more tightly controlled heat treatment and stress relieving processes. Helical gear profiles use a shallow helix angle to reduce axial loads and improve the operating reliability at larger shaft deflections. Overall they are some of the strongest gear set options available. However, no gear set is indestructible. One of the main limitations of the Subaru 5-speed transmission is the lack of rigidity in the shaft support bearings. As a result, with proper preparation a Subaru 6-speed can be made stronger than a 5-speed.
Ppg Gear Set
Ppg Transmissions
Is it possible to buy individual replacement parts if necessary? Yes, please contact us to obtain pricing.